Reservoir targeted vaccine against Borrelia burgdorferi: a new strategy to prevent Lyme disease transmission.

Abstract

A high prevalence of infection with Borrelia burgdorferi in ixodid ticks is correlated with a high incidence of Lyme disease. The transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic cycle: the reservoir host and the tick vector. In a prospective 5-year field trial, we show that oral vaccination of wild white-footed mice resulted in outer surface protein A-specific seropositivity that led to reductions of 23% and 76% in the nymphal infection prevalence in a cumulative, time-dependent manner (2 and 5 years, respectively), whereas the proportion of infected ticks recovered from control plots varied randomly over time. Significant decreases in tick infection prevalence were observed within 3 years of vaccine deployment. Implementation of such a long-term public health measure could substantially reduce the risk of human exposure to Lyme disease.

• Authors: Luciana Meirelles Richer, Dustin Brisson, Rita Melo, Richard S Ostfeld, Nordin Zeidner, Maria Gomes-Solecki
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 209 Issue 12 Pg. 1972-80 (Jun 15 2014) ISSN: 1537-6613 [Electronic] United States
• PMID: 24523510 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
• Copyright: © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• Antigens, Surface
• Bacterial Outer Membrane Proteins
• Bacterial Vaccines
• Lipoproteins
• Lyme Disease Vaccines
• OspA protein

Topics

• Administration, Oral
• Animals
• Antigens, Surface (immunology)
• Bacterial Outer Membrane Proteins (immunology)
• Bacterial Vaccines (immunology)
• Borrelia burgdorferi (immunology)
• Disease Reservoirs (microbiology, veterinary)
• Lipoproteins (immunology)
• Lyme Disease (immunology, prevention & control, transmission)
• Lyme Disease Vaccines (immunology)
• Mice
• Peromyscus (immunology, microbiology)
• Ticks (immunology, microbiology)
• Vaccination (methods)