Outcome of Intravenous Immunoglobulin-Transmitted HTLV-I, Hepatitis B, Hepatitis C, and HIV infections.

Abstract

OBJECTIVE(S):

Since each unit of Intravenous Immunoglobulin (IVIG) is obtained from different blood donors, blood-borne viral diseases is of high importance. We aimed at investigating the prevalence of various viral infections: Human T-cell Lymphotropic Virus Type 1 (HTLV-I), Hepatitis B (HBV), Hepatitis C (HCV), and Human Immunodeficiency Virus (HIV) among patients referred for IVIG therapy section in Mashhad University of Medical Sciences, Mashhad, Iran.

MATERIALS AND METHODS:

A prospective study was conducted on 130 IVIG recipients admitted to different wards of our Medical Centre: Immunology, Hematology, and Neurology, in 2010. After filling the informed consent form, a 5 cc blood sample was initially taken from each patient. Viral infections including HTLV-I Ab, HIV-Ab, HBsAg, HBc-Ab, and HBV-Ab were assessed using the ELISA technique before and after six three months treatment.

RESULTS:

Test results for HTLV-I Ab, HBsAg, HBc Ab, HIV Ab, and HCV Ab were negative in all cases before IVIG therapy. After receiving IVIG, two female cases with CIDP showed positive results for HBV Ab (0.8%) and HBS Ag (0.8%) with ELISA and only one patient confirmed with PCR. There was not any significant relation between HBV Ag (P=0.14) and HBC Ab with type of disorder (P=0.66).

CONCLUSION:

This study showed that HTLV-I viral replication and the other investigated viral transmissions do not occur in plasma; therefore, the IVIG products are safe.

• Authors: Mohsen Foroughipour, Farahzad Jabbari Azad, Reza Farid Hosseini, Abbas Shirdel, Amir Reza Khalighi, Hadis Yousefzadeh, Homa Sadri, Toktam Moghiman, Hossein Hekmatkhah
• Journal: Iranian journal of basic medical sciences (Iran J Basic Med Sci) Vol. 16 Issue 3 Pg. 221-4 (Mar 2013) ISSN: 2008-3866 [Print] Iran
• PMID: 24470866 (Publication Type: Journal Article)