Efficacy of endoscopic gastroduodenal stenting for gastric outlet obstruction due to unresectable advanced gastric cancer: a prospective multicenter study.

Abstract

BACKGROUND AND OBJECTIVES:

Gastroduodenal stents for gastric outlet obstruction due to unresectable advanced gastric cancer are increasingly used; however, their effects have not been fully evaluated.

METHODS:

A multicenter prospective observational study was performed. Patients were eligible if they had stage IV gastric cancer with a gastric outlet obstruction scoring system (GOOSS) score of 0 (no oral intake) or 1 (liquids only). Self-expandable metallic stents were delivered endoscopically. The effects of stents were evaluated.

RESULTS:

Twenty patients were enrolled and 18 were eligible (15 men, three women; median age, 70 years). Stent placement was successfully performed in all patients, with no complications. After stenting, a GOOSS score of 2 (soft solids only) or 3 (low-residue or full diet) was achieved in 13 (72%) patients. An improvement in the GOOSS score by one or more points was obtained in 16 (94%) patients. The median duration of fasting and hospital stay was 3 (range, 0-9) days and 18 (6-168) days, respectively. Chemotherapy was performed after stenting in 13 (72%) patients.

CONCLUSIONS:

Gastroduodenal stents are thought to be feasible, safe, and effective for gastric outlet obstruction due to unresectable advanced gastric cancer, with rapid clinical relief and a short hospital stay.

• Authors: Shunji Endo, Shuji Takiguchi, Yasuhiro Miyazaki, Kazuhiro Nishikawa, Hiroshi Imamura, Ko Takachi, Yutaka Kimura, Atsushi Takeno, Shigeyuki Tamura, Masaki Mori, Yuichiro Doki, Clinical Study Group of Osaka University (CSGO), Upper GI Group
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 109 Issue 3 Pg. 208-12 (Mar 2014) ISSN: 1096-9098 [Electronic] United States
• PMID: 24464867 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Serum Albumin

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Equipment Design
• Female
• Gastric Outlet Obstruction (etiology, therapy)
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Nutritional Status
• Palliative Care (methods)
• Prospective Studies
• Serum Albumin (metabolism)
• Stents
• Stomach Neoplasms (complications, drug therapy, pathology)
• Treatment Outcome