Prevalence of plasma lipid abnormalities and its association with glucose metabolism in Spain: the [email protected] study.

Abstract

INTRODUCTION:

Dyslipidemia is a significant contributor to the elevated CVD risk observed in type 2 diabetes mellitus. We assessed the prevalence of dyslipidemia and its association with glucose metabolism status in a representative sample of the adult population in Spain and the percentage of subjects at guideline-recommended LDL-C goals.

MATERIAL AND METHODS:

The [email protected] study is a national, cross-sectional population-based survey of 5728 adults.

RESULTS:

A total of 4776 subjects were studied. Dyslipidemia was diagnosed in 56.8% of subjects; only 13.2% of subjects were treated with lipid lowering drugs. Lipid abnormalities were found in 56.8% of Spanish adults: 23.3% with high LDL-C, 21.5% high TG, 35.8% high non-HDL-C, and 17.2% low HDL-C. Most normal subjects showed an LDL-C ≤ 3.36 mmol/l. Pre-diabetics presented similar proportion when considering a goal of 3.36 mmol/l, but only 35% of them reached an LDL-C goal ≤ 2.6 mmol/l. Finally, 45.3% of diabetics had an LDL-C ≤ 2.6 mmol/l, and only 11.3% achieved an LDL-C ≤ 1.8 mmol/l.

CONCLUSIONS:

Our study demonstrates a high prevalence of dyslipidemia in the adult Spanish population, and a low use of lipid-lowering drugs. Moreover, the number of subjects achieving their corresponding LDL-C goal is small, particularly in subjects at high cardiovascular risk, such as diabetics.

• Authors: Sergio Martinez-Hervas, Rafael Carmena, Juan F Ascaso, Jose T Real, Luis Masana, Miguel Catalá, Joan Vendrell, José Antonio Vázquez, Sergio Valdés, Inés Urrutia, Federico Soriguer, Manuel Serrano-Rios, Gemma Rojo-Martínez, Gemma Pascual-Manich, Emilio Ortega, Inmaculada Mora-Peces, Edelmiro Menéndez, Maria T Martínez-Larrad, Alfonso López-Alba, Ramón Gomis, Albert Goday, Juan Girbés, Sonia Gaztambide, Josep Franch, Elías Delgado, Conxa Castell, Luis Castaño, Roser Casamitjana, Alfonso Calle-Pascual, Elena Bordiú
• Journal: Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis (Clin Investig Arterioscler) 2014 May-Jun Vol. 26 Issue 3 Pg. 107-14 ISSN: 1578-1879 [Electronic] Spain
• PMID: 24461346 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Hypolipidemic Agents
• Glucose

Topics

• Adolescent
• Adult
• Aged
• Cardiovascular Diseases (etiology)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood)
• Dyslipidemias (complications, drug therapy, epidemiology)
• Female
• Glucose (metabolism)
• Humans
• Hypolipidemic Agents (therapeutic use)
• Male
• Middle Aged
• Prediabetic State (blood)
• Prevalence
• Risk Factors
• Spain (epidemiology)
• Young Adult