Risk factors for treatment failure of CO2 laser vaporization in cervical intraepithelial neoplasia 2.

Abstract

PURPOSE:

The aim of our study was to evaluate the risk factors for treatment failure of CO2 laser vaporization in patients with cervical intraepithelial neoplasia 2 (CIN2).

METHODS:

Medical records of patients who received either shallow or deep CO2 laser vaporization with biopsy-proven CIN2 during March 2007 to April 2011 were reviewed retrospectively. After laser vaporization, liquid-based cytology and human papilloma virus (HPV) DNA testing were checked in every follow-up visit. Treatment failure was defined when the follow-up biopsy was more than CIN2, needing secondary surgical treatment.

RESULTS:

During that period, 141 patients with CIN2 underwent CO2 laser vaporization. After laser ablation, 14 of 141 women needed the secondary treatment, a success rate of laser vaporization of 90.1 %. In multivariate analysis, the previous loop electrosurgical excision procedure (LEEP) history (adjusted OR = 13.649; P value = 0.025) and the ablation depth (adjusted OR = 11.279; P value = 0.006) were independent factors associated with treatment failure.

CONCLUSION:

Both ablation depth and previous LEEP history were the important factors increasing the risk for the treatment failure of CO2 laser vaporization in CIN2.

• Authors: Bo Sung Yoon, Seok Ju Seong, Taejong Song, Mi-La Kim, Mi Kyoung Kim
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 290 Issue 1 Pg. 115-9 (Jul 2014) ISSN: 1432-0711 [Electronic] Germany
• PMID: 24458427 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adult
• Aged
• Biopsy
• Colposcopes
• Female
• Human Papillomavirus DNA Tests
• Humans
• Laser Therapy (adverse effects, methods)
• Lasers, Gas (therapeutic use)
• Middle Aged
• Multivariate Analysis
• Retrospective Studies
• Risk Factors
• Treatment Failure
• Uterine Cervical Neoplasms (pathology, surgery)
• Uterine Cervical Dysplasia (pathology, surgery)