Abstract | OBJECTIVE: PATIENTS AND METHODS: RESULTS: Serum UA levels showed weak but significant positive correlations with external elastic membrane volume (baseline: r=0.236, P=0.02; 8-month follow-up: r=0.307, P=0.0009) and with plaque volume (baseline: r=0.263, P=0.007; 8-month follow-up: r=0.349, P=0.0001). Significant decreases in the fibrofatty and fibrous components and increases in the necrotic core and dense calcium components were observed during statin therapy. Serum UA (r=0.257, P=0.009) and unstable angina pectoris (r=0.208, P=0.02) correlated significantly with change in the calcified plaque volume, whereas the estimated glomerular filtration rate trended (r=-0.166, P=0.07). Multivariate regression analyses showed that UA was a significant independent predictor associated with an increase in the dense calcium plaque volume during statin therapy (β=0.244, P=0.03). CONCLUSION: In this preliminary study, serum UA levels correlated with coronary atherosclerosis before and during statin therapy. It remains unknown whether these correlations are a direct effect of UA itself or a marker of increased risk.
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Authors | Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 25
Issue 4
Pg. 343-8
(Jun 2014)
ISSN: 1473-5830 [Electronic] England |
PMID | 24448173
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Uric Acid
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Topics |
- Aged
- Angina, Unstable
(blood, diagnosis, therapy)
- Biomarkers
(blood)
- Coronary Artery Disease
(blood, diagnosis, therapy)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Male
- Middle Aged
- Multivariate Analysis
- Percutaneous Coronary Intervention
- Predictive Value of Tests
- Randomized Controlled Trials as Topic
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Ultrasonography, Interventional
- Uric Acid
(blood)
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