Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion.

Abstract

OBJECTIVE:

To investigate the effect of desferrioxamine (DFX) on ipsilateral and contralateral testis damage caused by experimental testis torsion and detorsion.

MATERIALS AND METHODS:

Forty rats were divided into five groups (n = 8): control, torsion (T), torsion + desferrioxamine (T + DFX), torsion/detorsion (T/D), and torsion/detorsion + desferrioxamine (T/D + DFX). The right testes of the rats were subjected to torsion and detorsion for 3 h each. Thirty minutes before the application of torsion and detorsion, DFX (100 mg/kg) was administered intramuscularly. Blood samples and testicular tissues were examined using specific biochemical and histopathological methods.

RESULTS:

Ipsilateral and contralateral testis tissue glutathione levels in the T group decreased compared with the control and T + DFX groups. Plasma glutathione peroxidase activity in the T, T/D, and T/D + DFX groups was lower than in the control group. Plasma catalase activity in the T and T/D groups decreased compared with the control group. Ipsilateral mean seminiferous tubule diameter of the T group was lower than that of the T + DFX group. The ipsilateral mean testis biopsy scores in the T and T/D groups were lower than in the control group.

CONCLUSION:

The administration of DFX prior to torsion may be useful only for preventing ischemic damage in ipsilateral and contralateral testes.

• Authors: Suleyman Ayvaz, Mustafa Inan, Burhan Aksu, Turan Karaca, Mustafa Cemek, Ahmet Ayaz, Umit Nusret Basaran, Mehmet Pul
• Journal: Journal of pediatric urology (J Pediatr Urol) Vol. 10 Issue 3 Pg. 550-8 (Jun 2014) ISSN: 1873-4898 [Electronic] England
• PMID: 24440694 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Siderophores
• Deferoxamine

Topics

• Animals
• Deferoxamine (administration & dosage)
• Disease Models, Animal
• Follow-Up Studies
• Male
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (etiology, pathology, prevention & control)
• Siderophores (administration & dosage)
• Spermatic Cord Torsion (complications, drug therapy, pathology)
• Testis (drug effects, pathology)
• Time Factors