Abstract | OBJECTIVES: METHODS: A 96-week randomized clinical trial was carried out. The primary endpoint was change in total cholesterol at 24 weeks. Secondary endpoints were changes in lipids other than total cholesterol, insulin sensitivity, total bilirubin, estimated glomerular filtration rate, and CD4 and CD8 cell counts, and the proportion of patients with plasma HIV RNA < 50 HIV-1 RNA copies/mL and study drug discontinuation because of adverse effects at 24 weeks. Analyses were intent-to-treat. RESULTS: CONCLUSIONS:
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Authors | E Martinez, A Gonzalez-Cordon, E Ferrer, P Domingo, E Negredo, F Gutierrez, J Portilla, A Curran, D Podzamczer, J Murillas, J I Bernardino, I Santos, J A Carton, J Peraire, J Pich, I Perez, J M Gatell, ATADAR Study Group |
Journal | HIV medicine
(HIV Med)
Vol. 15
Issue 6
Pg. 330-8
(Jul 2014)
ISSN: 1468-1293 [Electronic] England |
PMID | 24417772
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 British HIV Association. |
Chemical References |
- HIV Protease Inhibitors
- Lipids
- Oligopeptides
- Pyridines
- RNA, Viral
- Sulfonamides
- Atazanavir Sulfate
- Ritonavir
- Bilirubin
- Darunavir
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Topics |
- Adult
- Atazanavir Sulfate
- Bilirubin
- CD4 Lymphocyte Count
- CD8-Positive T-Lymphocytes
(cytology)
- Darunavir
- Drug Therapy, Combination
(methods)
- Female
- Glomerular Filtration Rate
- HIV Infections
(blood, drug therapy, physiopathology)
- HIV Protease Inhibitors
(adverse effects, therapeutic use)
- Humans
- Hyperbilirubinemia
(chemically induced)
- Lipids
(blood)
- Male
- Middle Aged
- Oligopeptides
(administration & dosage)
- Prospective Studies
- Pyridines
(administration & dosage)
- RNA, Viral
(analysis)
- Ritonavir
(administration & dosage)
- Spain
- Sulfonamides
(administration & dosage)
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