Over-expression of the overexpressed in lung cancer-1 is associated with poor prognosis in colorectal cancer.

Abstract

BACKGROUND/AIM:

The overexpressed in lung cancer-1 (OLC1) protein is overexpressed in a variety of human tumors. The purpose of the present study was to determine whether increased expression of OLC1 is associated with colorectal cancer.

MATERIALS AND METHODS:

OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining (IHC). Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis.

RESULTS:

Immunohistochemical results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1. OLC1 expression was significantly correlated with UICC stage (p<0.001) and histological differentiation (p<0.001) in colorectal cancer patients. The 5-year overall survival (OS) rates in patients with strong-positive and weak OLC1 staining were 16.6% and 95.3%, respectively (p<0.0001).

CONCLUSION:

OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.

• Authors: Jinglei Liu, Hongtao Song, Lei Yao, Yanlong Liu, Youxue Zhang, Hongli Zhao, Hongfei Ji, Yan Wang
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 1 Pg. 367-72 (Jan 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24403489 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• IST1 protein, human
• Oncogene Proteins

Topics

• Adenocarcinoma (metabolism, mortality, pathology)
• Biomarkers, Tumor (metabolism)
• Case-Control Studies
• Colon (metabolism)
• Colorectal Neoplasms (metabolism, mortality, pathology)
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Staging
• Oncogene Proteins (metabolism)
• Prognosis
• Rectum (metabolism)
• Survival Rate