[Resection and postoperative multidisciplinary treatment for hepatocellular carcinoma with massive portal venous tumor thrombus-a single-center experience].

Abstract

BACKGROUND:

Patients with advanced hepatocellular carcinoma( HCC) with massive portal venous tumor thrombus (PVTT) face a dismal prognosis as no standard therapy has been defined. A cancer board was established at our hospital 5 years ago.

OBJECTIVE:

The aim of this retrospective study was to evaluate our surgical and multidisciplinary treatment for HCC with massive PVTT.

PATIENTS AND METHODS:

From July 2007 to June 2012, 8 patients with HCC with PVTT extending into the main portal trunk were treated. Hemihepatectomy and PVTT removal were performed in 4 patients. Postoperative multidisciplinary treatment included transarterial chemoembolization, hepatic arterial infusion therapy, and administration of sorafenib. In 1 patient, intrahepatic recurrence and bilateral adrenal metastases were resected.

RESULTS:

There was no in- hospital mortality. The median postoperative hospital stay was 30 days. The overall median survival for patients who underwent surgery and who did not undergo surgery was 344.5 days and 67 days, respectively.

CONCLUSIONS:

Resection for HCC with PVTT extending into the main portal trunk is acceptable at medium-scale teaching hospitals in Japan. Surgery and postoperative multidisciplinary therapy may improve the outcome of patients with HCC with massive PVTT.

• Authors: Masaki Kashiwazaki, Naoki Hama, Daisuke Takiuchi, Kozo Noguchi, Tomoki Hata, Kei Asukai, Rie Hamano, Shinichi Yoshioka, Hirofumi Miki, Masaki Tsujie, Koji Yano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 12 Pg. 1675-7 (Nov 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 24393885 (Publication Type: English Abstract, Journal Article)

Topics

• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular (complications, therapy)
• Combined Modality Therapy
• Female
• Humans
• Liver Neoplasms (complications, therapy)
• Male
• Middle Aged
• Portal Vein
• Treatment Outcome
• Venous Thrombosis (etiology, therapy)