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Choroidal metastases responsive to crizotinib therapy in a lung adenocarcinoma patient with ALK 2p23 fusion identified by ALK immunohistochemistry.

AuthorsYan Feng, Arun D Singh, Christopher Lanigan, Raymond R Tubbs, Patrick C Ma
JournalJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol) Vol. 8 Issue 12 Pg. e109-11 (Dec 2013) ISSN: 1556-1380 [Electronic] United States
PMID24389446 (Publication Type: Case Reports, Journal Article)
Chemical References
  • DNA, Neoplasm
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyridines
  • Crizotinib
  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Receptor Protein-Tyrosine Kinases
Topics
  • Adenocarcinoma (drug therapy, genetics, pathology)
  • Anaplastic Lymphoma Kinase
  • Choroid Neoplasms (drug therapy, genetics, secondary)
  • Chromosomes, Human, Pair 2 (genetics)
  • Crizotinib
  • DNA, Neoplasm (genetics)
  • Female
  • Gene Fusion
  • Gene Rearrangement
  • Humans
  • Immunoenzyme Techniques
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms (drug therapy, genetics, pathology)
  • Middle Aged
  • Prognosis
  • Protein Kinase Inhibitors (therapeutic use)
  • Pyrazoles (therapeutic use)
  • Pyridines (therapeutic use)
  • Receptor Protein-Tyrosine Kinases (genetics, metabolism)
  • Translocation, Genetic (genetics)

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