Abstract | BACKGROUND:
Hypothyroidism induced by an autoimmune process is associated with neuropsychiatric symptoms and metabolic abnormalities in the brain. The aim of this study was to examine the relationship between autoimmune thyroiditis and regional brain function in hypothyroid patients. METHODS: RESULTS: Serum levels of anti-TG antibodies in hypothyroid patients were significantly correlated with glucose metabolism in the perigenual anterior cingulate cortex, a brain region previously shown to regulate affect and emotional homeostasis. CONCLUSION: Thyroid autoimmune processes may play an important role in the still poorly defined pathogenic correlates of disturbed function in brain regions critically involved in emotional processing in hypothyroid conditions.
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Authors | M Pilhatsch, F Schlagenhauf, D Silverman, S Berman, E D London, D Martinez, P C Whybrow, M Bauer |
Journal | Brain, behavior, and immunity
(Brain Behav Immun)
Vol. 37
Pg. 73-7
(Mar 2014)
ISSN: 1090-2139 [Electronic] Netherlands |
PMID | 24365060
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Antibodies
(blood)
- Brain
(diagnostic imaging, metabolism)
- Female
- Fluorodeoxyglucose F18
- Gyrus Cinguli
(diagnostic imaging, immunology, metabolism)
- Humans
- Hypothyroidism
(complications, diagnostic imaging, metabolism)
- Male
- Middle Aged
- Positron-Emission Tomography
- Thyroiditis, Autoimmune
(complications, diagnostic imaging, immunology, metabolism)
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