Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting.
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| Abstract |
A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
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| Authors | James J DiNicolantonio, Craig J Beavers, Arthur R Menezes, Carl J Lavie, James H O'Keefe, Pascal Meier, András Vorobcsuk, Dániel Aradi, András Komócsi, Saurav Chatterjee, Fabrizio D'Ascenzo, Mauro Gasparini, Jasper Brugts, Giuseppe Biondi-Zoccai |
| Journal | The American journal of cardiology (Am J Cardiol) Vol. 113 Issue 3 Pg. 565-9 (Feb 01 2014) ISSN: 1879-1913 [Electronic] United States |
| PMID | 24332247 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review) |
| Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
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