A prospective cohort study.
SETTING: All hospitals in Denmark.
PARTICIPANTS: 44 330 patients with VTE were included in the study. Of these 3914 were receiving
statin therapy at baseline. Patients receiving
statins were older (68±11 compared to 62±18 years), had more comorbidity and used more medications. The incidence rate for recurrent VTE was 24.4 (95% CI 22.8 to 26.2) per 1000 person-years among
statin users and 48.5 (95% CI 47.4 to 49.7) per 1000 person-years among non-
statin users.
Statin use was associated with a significantly lower risk of a recurrent VTE, adjusted HR 0.74 (95% CI 0.68 to 0.80), compared with no
statin use. The association between
statin use and risk of recurrent VTE was significantly affected by age. Among younger individuals (≤80 years),
statin use was associated with lower risk of recurrent VTE, HR 0.70 (95% CI 0.65 to 0.76) whereas in older individuals (>80 years)
statin use was significantly associated with higher risk of recurrent VTE, HR 1.28 (95% CI 1.02 to 1.60), p for interaction=<0.0001.
CONCLUSIONS: