Abstract | BACKGROUND: METHODS: Nine patients underwent isolated intestinal transplant and 2 patients had multivisceral transplant. Immunosuppression was represented by FK and steroids plus induction with alemtuzumab, daclizumab, or thymoglobulin. Average age at transplant was 33.5 years. We reported 1 graftectomy, followed by retransplantation. RESULTS: Seven patients are currently alive with working small bowel; cause of death was infection in the 4 remaining cases. In 9 isolated intestinal transplants, we performed different digestive reconstructions to allow gastric emptying. In 2 cases we were forced, after transplant, to perform ileostomy to improve intestinal motility. Graft and patient survival after 5 years are 60% and 70%, respectively, while after 10 years, 45% and 56%, respectively. CONCLUSIONS: Adults with CIPO and irreversible TPN complications benefit from isolated intestinal transplant with different surgical techniques to empty the native stomach: this strategy achieves good gastric emptying, with effective establishment of oral feeding and graft and patient survivals comparable to isolated intestinal transplant for short bowel syndrome.
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Authors | A Lauro, C Zanfi, S Pellegrini, F Catena, M Cescon, N Cautero, V Stanghellini, L Pironi, A D Pinna |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 45
Issue 9
Pg. 3351-5
(Nov 2013)
ISSN: 1873-2623 [Electronic] United States |
PMID | 24182815
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Intestinal Pseudo-Obstruction
(surgery)
- Intestines
(transplantation)
- Male
- Middle Aged
- Treatment Outcome
- Young Adult
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