A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients.

Abstract

BACKGROUND:

Peanut allergy is a major public health problem that affects 1% of the population and has no effective therapy.

OBJECTIVE:

To examine the safety and efficacy of oral desensitization in peanut-allergic children in combination with a brief course of anti-IgE mAb (omalizumab [Xolair]).

METHODS:

We performed oral peanut desensitization in peanut-allergic children at high risk for developing significant peanut-induced allergic reactions. Omalizumab was administered before and during oral peanut desensitization.

RESULTS:

We enrolled 13 children (median age, 10 years), with a median peanut-specific IgE level of 229 kU(A)/L and a median total serum IgE level of 621 kU/L, who failed an initial double-blind placebo-controlled food challenge at peanut flour doses of 100 mg or less. After pretreatment with omalizumab, all 13 subjects tolerated the initial 11 desensitization doses given on the first day, including the maximum dose of 500 mg peanut flour (cumulative dose, 992 mg, equivalent to >2 peanuts), requiring minimal or no rescue therapy. Twelve subjects then reached the maximum maintenance dose of 4000 mg peanut flour per day in a median time of 8 weeks, at which point omalizumab was discontinued. All 12 subjects continued on 4000 mg peanut flour per day and subsequently tolerated a challenge with 8000 mg peanut flour (equivalent to about 20 peanuts), or 160 to 400 times the dose tolerated before desensitization. During the study, 6 of the 13 subjects experienced mild or no allergic reactions, 5 subjects had grade 2 reactions, and 2 subjects had grade 3 reactions, all of which responded rapidly to treatment.

CONCLUSIONS:

Among children with high-risk peanut allergy, treatment with omalizumab may facilitate rapid oral desensitization and qualitatively improve the desensitization process.

• Authors: Lynda C Schneider, Rima Rachid, Jennifer LeBovidge, Emily Blood, Mudita Mittal, Dale T Umetsu
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 132 Issue 6 Pg. 1368-74 (Dec 2013) ISSN: 1097-6825 [Electronic] United States
• PMID: 24176117 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Chemical References

• Allergens
• Anti-Allergic Agents
• Antibodies, Anti-Idiotypic
• Antibodies, Monoclonal, Humanized
• Omalizumab

Topics

• Administration, Oral
• Adolescent
• Adult
• Allergens (immunology, therapeutic use)
• Anti-Allergic Agents (administration & dosage, adverse effects)
• Antibodies, Anti-Idiotypic (administration & dosage, adverse effects)
• Antibodies, Monoclonal, Humanized (administration & dosage, adverse effects)
• Arachis (immunology)
• Chemotherapy, Adjuvant
• Child
• Desensitization, Immunologic (methods)
• Female
• Humans
• Male
• Omalizumab
• Peanut Hypersensitivity (immunology, therapy)
• Pilot Projects
• Population Groups
• Risk
• Treatment Outcome
• Young Adult