D-psicose increases energy expenditure and decreases body fat accumulation in rats fed a high-sucrose diet.

Abstract

We investigated the anti-obesity effects of D-psicose by increasing energy expenditure in rats pair-fed the high-sucrose diet (HSD). Wistar rats were divided into two dietary groups: HSD containing 5% cellulose (C) and 5% d-psicose (P). The C dietary group was further subdivided into two groups: rats fed the C diet ad libitum (C-AD) and pair-fed the C diet along with those in the P group (C-PF). Resting energy expenditure during darkness and lipoprotein lipase activity in the soleus muscle were significantly higher in the P group than in the C-PF group. Serum levels of glucose, leptin and adiponectin; glucose-6-phosphate dehydrogenase activities in the liver and perirenal adipose tissue; and body fat accumulation were all significantly lower in the P group than in the C-PF group. The anti-obesity effects of D-psicose could be induced not only by suppressing lipogenic enzyme activity but also by increasing EE in rats.

• Authors: Masaru Ochiai, Kana Onishi, Takako Yamada, Tetsuo Iida, Tatsuhiro Matsuo
• Journal: International journal of food sciences and nutrition (Int J Food Sci Nutr) Vol. 65 Issue 2 Pg. 245-50 (Mar 2014) ISSN: 1465-3478 [Electronic] England
• PMID: 24144428 (Publication Type: Journal Article)

Chemical References

• Anti-Obesity Agents
• Dietary Sucrose
• psicose
• Fructose

Topics

• Adipose Tissue (drug effects, metabolism)
• Animals
• Anti-Obesity Agents (pharmacology)
• Diet
• Dietary Sucrose (adverse effects)
• Energy Metabolism (drug effects)
• Fructose (pharmacology)
• Male
• Obesity (metabolism, prevention & control)
• Rats
• Rats, Wistar