Presence of keratin-specific antibody-forming cells in palatine tonsils of patients with pustulosis palmaris et plantaris (PPP) and its correlation with prognosis after tonsillectomy.

Abstract

CONCLUSION:

Keratin-specific immune responses in tonsils may be associated with the pathogenesis of pustulosis palmaris et plantaris (PPP). Evaluation of keratin-specific immune responses in tonsils might be useful to predict the effectiveness of tonsillectomy for patients with PPP.

OBJECTIVES:

The aim of the present study was to clarify the role of keratin-specific immune responses in the pathogenesis of PPP in tonsils. It has been reported that anti-keratin antibodies in serum were higher in patients with PPP and decreased after tonsillectomy, indicating that anti-keratin antibodies might be generated in tonsils.

METHODS:

In order to demonstrate the presence of keratin-specific immune responses in tonsils, the numbers of keratin-specific antibody-forming cells (AFCs) in tonsillar and peripheral blood lymphocytes were examined by enzyme-linked immunospot assay. The prognosis of PPP was compared after tonsillectomy.

RESULTS:

The numbers of keratin-specific IgM and IgG AFCs in tonsils and of IgG AFCs in peripheral blood were significantly increased in patients with PPP. The numbers of keratin-specific IgG AFCs in peripheral blood correlated positively with tonsil and serum IgG antibodies specific to keratin. Our data show that a good prognosis in patients with PPP depended on the numbers of keratin-specific IgG and IgM AFCs in peripheral blood and the levels of keratin-specific IgG antibodies in serum being significantly decreased 6 months after tonsillectomy.

• Authors: Yoichiro Tanimoto, Satoshi Fukuyama, Norimitsu Tanaka, Jun-Ichiro Ohori, Yukari Tanimoto, Yuichi Kurono
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 134 Issue 1 Pg. 79-87 (Jan 2014) ISSN: 1651-2251 [Electronic] England
• PMID: 24138121 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Keratins

Topics

• Adolescent
• Adult
• Antibody-Producing Cells
• Case-Control Studies
• Female
• Humans
• Keratins (immunology)
• Male
• Middle Aged
• Palatine Tonsil (immunology, pathology)
• Prognosis
• Psoriasis (blood, immunology, surgery)
• Tonsillectomy
• Young Adult