Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats.

Abstract

Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti-inflammatory effects. However, the mechanisms by which PPAR-γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR-γ ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate-induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high-lipid diet-induced hyperlipidemia and SAP.

• Authors: Batur Niyaz, Kai-Liang Zhao, Li-Min Liu, Chen Chen, Wen-Hong Deng, Teng Zuo, Qiao Shi, Wei-Xing Wang
• Journal: Experimental and therapeutic medicine (Exp Ther Med) Vol. 6 Issue 4 Pg. 989-994 (Oct 2013) ISSN: 1792-0981 [Print] Greece
• PMID: 24137303 (Publication Type: Journal Article)