Abstract | BACKGROUND: METHODS:
Tumor and adjacent normal tissues of 395 nephrectomized patients were immunostained for RECK and EMMPRIN on a tissue microarray. RESULTS: RECK strongly decreased in renal cell carcinoma compared to normal counterparts (Wilcoxon signed rank test, P<0.001), and it discriminated tumor entities showing the highest expression in oncocytomas. EMMPRIN, however, could be significantly correlated to pT stage and Fuhrman grading (Spearman's correlation coefficient rs=0.289 and rs=0.382, respectively). Higher expression of EMMPRIN was associated with decreased overall survival in Kaplan-Meier analysis (P<0.001), and the EMMPRIN level could independently predict survival for cases without metastasis and involvement of lymph nodes. Decreased RECK expression was confirmed by Western blotting in tissue of eight normal/ tumor matches of patients after radical nephrectomy, whereas the EMMPRIN pattern appeared to be heterogeneous. CONCLUSIONS:
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Authors | Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung, Andreas Erbersdobler |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 11
Pg. 258
(Oct 16 2013)
ISSN: 1479-5876 [Electronic] England |
PMID | 24131772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BSG protein, human
- GPI-Linked Proteins
- RECK protein, human
- Basigin
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Topics |
- Basigin
(metabolism)
- Blotting, Western
- Carcinoma, Renal Cell
(enzymology, metabolism, pathology)
- Female
- GPI-Linked Proteins
(metabolism)
- Humans
- Kidney Neoplasms
(enzymology, metabolism, pathology)
- Male
- Middle Aged
- Nephrectomy
- Prognosis
- Tissue Array Analysis
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