Abstract | AIM: MATERIALS AND METHODS: A total of 134 patients who received laser ablation for treatment of CIN3 were enrolled in this study. During the follow-up period, patients were followed with cytological and colposcopic evaluations. Recurrence of CIN3 was regarded as the primary end-point. HPV genotype was tested before and after treatment. Post-treatment cumulative recurrence rates were estimated and comparisons by both patient age and HPV genotype were performed. RESULTS: Overall cumulative recurrence rate of CIN3 in the first year after treatment was 22.6% for all patients. No significant correlation was shown between patient age and recurrence. Patients infected by specific genotypes (16, 18, 31, 33, 52, and 58) frequently failed to clear the infection after treatment. The 1-year recurrence-free survival in those positive after treatment for eight high-risk genotypes (16, 18, 31, 33, 35, 45, 52, and 58) was significantly lower (66.7%), compared to that in those positive for other high-risk types (78.6%). The recurrence-free survival of those who remained HPV-positive after treatment was significantly lower than those who turned negative. CONCLUSION:
Laser ablation should be performed prudently with appropriate patient counseling about recurrence rate. Considering its minimal invasiveness, laser ablation is effective, especially for young patients who are negative for eight high-risk genotypes. With regard to HPV testing, although genotyping has significant value for predicting recurrence, screening for all genotypes warrants further evaluation.
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Authors | Kanako Inaba, Kazunori Nagasaka, Kei Kawana, Takahide Arimoto, Yoko Matsumoto, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Shiho Miura, Kenbun Sone, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Shiro Kozuma, Tomoyuki Fujii |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 40
Issue 2
Pg. 554-60
(Feb 2014)
ISSN: 1447-0756 [Electronic] Australia |
PMID | 24118526
(Publication Type: Journal Article)
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Copyright | © 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology. |
Topics |
- Ablation Techniques
- Adult
- Aged
- Alphapapillomavirus
(genetics)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Genotype
- Humans
- Laser Therapy
- Middle Aged
- Neoplasm Recurrence, Local
(virology)
- Papillomavirus Infections
(complications, virology)
- Retrospective Studies
- Time Factors
- Uterine Cervical Neoplasms
(surgery, virology)
- Uterine Cervical Dysplasia
(surgery, virology)
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