Cytotoxic Compounds from Brucea mollis.

Abstract

Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one-and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1-4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.

• Authors: Mai Hung Thanh Tung, Ho Viet Duc, Tran Thu Huong, Nguyen Thanh Duong, Do Thi Phuong, Do Thi Thao, Bui Huu Tai, Young Ho Kim, Tran The Bach, Nguyen Manh Cuong
• Journal: Scientia pharmaceutica (Sci Pharm) 2013 Jul-Sep Vol. 81 Issue 3 Pg. 819-31 ISSN: 2218-0532 [Electronic] Switzerland
• PMID: 24106661 (Publication Type: Journal Article)