Abstract | PURPOSE: MATERIAL AND METHOD: Forty two healthy volunteers participated in the study. They were divided into two groups. In one group aspirin was given orally, daily, for one week in a dose of 75 mg (n=25). The subjects from the second group received one 300 mg dose of the drug (n=17). In both groups the blood was taken 4h after the last dose of aspirin. The following sphingolipid intermediates were quantified using high-pressure liquid chromatography: sphinganine, sphingosine, sphingosine-1-phosphate (S1P), sphinganine-1-phosphate (SA1P) and ceramide. RESULTS: It was found that lower dose of aspirin increased the level of S1P and ceramide in erythrocytes (by 23 and 37%, respectively) having no effect on plasma and platelet sphingolipid levels. Higher dose of the drug reduced S1P and SA1P concentration in the plasma (by 16 and 10%, respectively). CONCLUSION: We conclude that aspirin interferes with sphingolipid metabolism in blood and that this effect depends on a dose of the drug. Since S1P is a potent cardioprotectant, the reduction in its plasma concentration after the loading dose of aspirin could be undesired side effect of the drug.
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Authors | M Knapp, A Lisowska, P Knapp, M Baranowski |
Journal | Advances in medical sciences
(Adv Med Sci)
Vol. 58
Issue 2
Pg. 274-81
( 2013)
ISSN: 1898-4002 [Electronic] Netherlands |
PMID | 24101372
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Ceramides
- Hemoglobins
- Lysophospholipids
- Platelet Aggregation Inhibitors
- Sphingolipids
- sphingosine 1-phosphate
- Sphingosine
- safingol
- Aspirin
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, blood, pharmacology)
- Aspirin
(administration & dosage, blood, pharmacology)
- Blood Platelets
(drug effects, metabolism)
- Ceramides
(blood, metabolism)
- Dose-Response Relationship, Drug
- Erythrocytes
(drug effects, metabolism)
- Female
- Healthy Volunteers
- Hemoglobins
(metabolism)
- Humans
- Lysophospholipids
(blood, metabolism)
- Male
- Platelet Aggregation Inhibitors
(administration & dosage, blood, pharmacology)
- Platelet Count
- Sphingolipids
(blood, metabolism)
- Sphingosine
(analogs & derivatives, blood, metabolism)
- Young Adult
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