Matrix metalloproteinase-9 as a potential tumor marker in breast cancer.

Abstract

This study aimed to detect the comparative expression and activity of matrix metalloproteinase-9 (MMP-9) and its correlation with known pathological parameters such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) in 81 malignant breast tumors and adjacent normal breast tissues and in blood sera of these patients from different clinical TNM stages (ductal carcinoma in situ to T4) of breast cancer. MMP-9 was highly expressed in node-positive tumors and the preoperative blood serum of patients, but MMP-9 activity was appreciably inhibited in blood serum samples collected after surgery. The mature form of MMP-9 (84 kD) was expressed only in clinical stage III tumors (T2-4). Appreciable reduction of tissue inhibitor of metalloproteinase 1, phosphorylation of epidermal growth factor receptor, and translocation of nuclear factor-κΒ suggested their possible role in MMP-9 activation in HER2-positive breast cancer Overexpression and activation of MMP-9 predicted a higher stage of hormone-sensitive ductal breast carcinoma. Downregulation of the endogenous inhibitor of MMP-9, tissue inhibitor of metalloproteinase 1, and translocation of the transcription factor nuclear factor-κΒ in tumors may have an appreciable role in the overexpression of MMP-9. However, MMP-9 activation was not correlated with expression of estrogen and progesterone receptors. Evaluation of MMP-9 expression may provide valuable information about breast cancer treatment.

• Authors: Durga Prasad Nanda, Hrishikesh Sil, Shuvojit Moulik, Jaydip Biswas, Shyam Sundar Mandal, Amitava Chatterjee
• Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer (J Environ Pathol Toxicol Oncol) Vol. 32 Issue 2 Pg. 115-29 ( 2013) ISSN: 2162-6537 [Electronic] United States
• PMID: 24099425 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• NF-kappa B
• Receptors, Estrogen
• Receptors, Progesterone
• TIMP1 protein, human
• Tissue Inhibitor of Metalloproteinase-1
• EGFR protein, human
• ERBB2 protein, human
• ErbB Receptors
• Receptor, ErbB-2
• Matrix Metalloproteinase 9

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis, genetics, metabolism)
• Breast Neoplasms (metabolism, pathology, surgery)
• Carcinoma, Intraductal, Noninfiltrating (metabolism, pathology)
• ErbB Receptors (metabolism)
• Female
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Humans
• Matrix Metalloproteinase 9 (analysis, blood, genetics, metabolism)
• Menopause
• Middle Aged
• NF-kappa B (metabolism)
• Prognosis
• Receptor, ErbB-2 (metabolism)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Tissue Inhibitor of Metalloproteinase-1 (genetics, metabolism)
• Young Adult