Abstract |
In the current work the kinetics of dehydration of ziprasidone hydrochloride monohydrate was studied by nonisothermal thermogravimetry. Ziprasidone hydrochloride monohydrate was heated from 30 to 150° with a heating rate of 5° per min under nitrogen gas atmosphere and weight loss data were collected. Powder X-ray difraction was used to characterize the solid before and after dehydration. The well accepted Coats-Redfern model fitting approach was applied to the thermogravimetry data for the kinetic analysis. Thirteen solid state reaction models were studied; among them one-dimensional diffusion model was found to be the best fit model for this reaction with an excellent correlation 0.9994. The Arrhenius parameters, activation energy, and pre-exponential factor were determined, the values were found to be 28 k.cal/mol and 9.53×10(13) sec(-1), respectively.
|
Authors | A Ravikiran, M Arthanareeswari, P Kamaraj, C Praveen |
Journal | Indian journal of pharmaceutical sciences
(Indian J Pharm Sci)
Vol. 75
Issue 3
Pg. 361-4
(May 2013)
ISSN: 0250-474X [Print] India |
PMID | 24082354
(Publication Type: Journal Article)
|