Abstract | BACKGROUND: METHODS: A total of 119 matched-related allogeneic- HSCTs (allo-HSCTs) were done in 114 patients (men 76, women 38) aged between 2 and 60 years. Peripheral blood stem cells (n=75) and bone marrow (n=43) were used as the source of stem cells. RESULTS: The overall survival was 62.3% (71/114) at a median follow-up of 34 months. Graft versus host disease (GVHD) was seen in 42 (36.8%) patients; grade III/IV acute GVHD in 17 (15%) and chronic GVHD in 24 (21%) patients. There were 4 (3.5%) graft rejections and one nonengraftment. The overall mortality was 37.7% (n=43) and the main causes of death were GVHD (32%), infections (26%), relapse (23%) and regimen-related toxicity (11%). CONCLUSION: Our results are comparable to published data in most disease conditions. With improvements in GVHD prophylaxis and better supportive care, we need to further reduce our mortality and morbidity.
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Authors | V Nair, A Sharma, S DAS, S Sharma, N Grover, J Kaur |
Journal | The National medical journal of India
(Natl Med J India)
2013 Jan-Feb
Vol. 26
Issue 1
Pg. 6-11
ISSN: 0970-258X [Print] India |
PMID | 24066986
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2012, NMJI. |
Topics |
- Adolescent
- Adult
- Bone Marrow Diseases
(therapy)
- Child
- Child, Preschool
- Female
- Genetic Diseases, Inborn
(therapy)
- Graft Rejection
(etiology)
- Graft vs Host Disease
(etiology)
- Hematologic Neoplasms
(therapy)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Hospitals, Military
- Humans
- India
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Survival Rate
- Transplantation, Homologous
- Young Adult
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