Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

Abstract

Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.

• Authors: Shahab Uddin, Azhar R Hussain, Omar S Khan, Khawla S Al-Kuraya
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 2 Pg. 871-9 (Feb 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 24014051 (Publication Type: Journal Article, Review)

Chemical References

• Leptin
• Receptors, Leptin

Topics

• Adipose Tissue (metabolism, pathology)
• Carcinogenesis (metabolism)
• Colorectal Neoplasms (genetics, metabolism, pathology)
• Energy Metabolism
• Gene Expression Regulation, Neoplastic
• Homeostasis
• Humans
• Leptin (genetics, metabolism)
• Receptors, Leptin (genetics, metabolism)
• Signal Transduction