Overexpression of transglutaminase 4 and prostate cancer progression: a potential predictor of less favourable outcomes.

Abstract

Transglutaminase 4 has been shown to enhance various biological properties of prostate cancer cells, e.g., cell-matrix adhesion, invasiveness and the epithelial-mesenchymal transition. The objectives of this study were to investigate the associations between transglutaminase 4 expression and the established features and biochemical recurrence of prostate cancer. Transglutaminase 4 immunostaining was performed on a tissue microarray. The expression of transglutaminase 4 was evaluated by a scoring method based on the intensity and extent of staining. The clinical and pathological information was obtained through a review of medical records. Follow-up data were obtained by consulting the hospital medical records and the prostate cancer database of our department and by contacting patients or family members. We then compared the transglutaminase 4 expression levels between the prostate cancer tissues and the paracarcinoma tissues and evaluated the correlation of transglutaminase 4 expression with the clinical parameters and biochemical recurrence of prostate cancer. Our results indicated that the transglutaminase 4 staining was significantly higher in tumour tissue than in paracarcinoma tissue (P<0.001) and was positively associated with higher Gleason score (P<0.001) and higher prostate-specific antigen level (P=0.005). Patients with transglutaminase 4 overexpression experienced shorter biochemical recurrence-free survival after surgery (P=0.042) in the univariate analysis but not in the multivariate analysis (P=0.139), which indicated that transglutaminase 4 may serve as a potential predictor of biochemical recurrence of prostate cancer.

• Authors: Zhi Cao, Yang Wang, Zhi-Yong Liu, Zhen-Sheng Zhang, Shan-Cheng Ren, Yong-Wei Yu, Meng Qiao, Bei-Bei Zhai, Ying-Hao Sun
• Journal: Asian journal of andrology (Asian J Androl) Vol. 15 Issue 6 Pg. 742-6 (Nov 2013) ISSN: 1745-7262 [Electronic] China
• PMID: 23974364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• transglutaminase 4
• Transglutaminases

Topics

• Aged
• Disease Progression
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (enzymology, pathology)
• Transglutaminases (metabolism)