Abstract | BACKGROUND: To reduce the risk of bronchopulmonary dysplasia in extremely-low-birth-weight infants, clinicians attempt to minimize the use of endotracheal intubation by the early introduction of less invasive forms of positive airway pressure. METHODS: RESULTS: Of the 497 infants assigned to nasal IPPV for whom adequate data were available, 191 died or survived with bronchopulmonary dysplasia (38.4%), as compared with 180 of 490 infants assigned to nasal CPAP (36.7%) (adjusted odds ratio, 1.09; 95% confidence interval, 0.83 to 1.43; P=0.56). The frequencies of air leaks and necrotizing enterocolitis, the duration of respiratory support, and the time to full feedings did not differ significantly between treatment groups. CONCLUSIONS: Among extremely-low-birth-weight infants, the rate of survival to 36 weeks of postmenstrual age without bronchopulmonary dysplasia did not differ significantly after noninvasive respiratory support with nasal IPPV as compared with nasal CPAP. (Funded by the Canadian Institutes of Health Research; NIPPV ClinicalTrials.gov number, NCT00433212; Controlled-Trials.com number, ISRCTN15233270.).
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Authors | Haresh Kirpalani, David Millar, Brigitte Lemyre, Bradley A Yoder, Aaron Chiu, Robin S Roberts, NIPPV Study Group |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 369
Issue 7
Pg. 611-20
(Aug 15 2013)
ISSN: 1533-4406 [Electronic] United States |
PMID | 23944299
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Bronchopulmonary Dysplasia
(epidemiology, prevention & control)
- Continuous Positive Airway Pressure
(adverse effects)
- Female
- Humans
- Infant, Extremely Low Birth Weight
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(mortality)
- Intermittent Positive-Pressure Ventilation
(adverse effects)
- Male
- Retinopathy of Prematurity
(epidemiology)
- Survival Rate
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