SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects.

Abstract

BACKGROUND:

Serum amyloid A (SAA) was reported to be associated with insulin resistance and type-2 diabetes. The present study aimed to investigate the association of SAA genetic polymorphisms with plasma glucose levels in non-diabetic subjects.

METHODS:

All participants (n=1220) were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. Five single-nucleotide polymorphisms (SNPs) (rs2229338, rs12218, rs4638289, rs7131332 and rs11603089) of SAA gene were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis.

RESULTS:

In the present study, we found rs2229338, rs4638289 and rs12218 were significantly associated with plasma glucose levels in a dominate model, recessive model or additive model before and after multivariate adjustment (all p<0.05). These associations were not found in rs7131332 and rs11603089 before and after adjustment of key co-variants.

CONCLUSIONS:

The genetic polymorphisms of SAA1 were associated with plasma glucose levels in non-diabetic subjects.

• Authors: Xiang Xie, Yi-Tong Ma, Yi-Ning Yang, Xiao-Mei Li, Ying-Ying Zheng, Zhen-Yan Fu, Xiang Ma, Fen Liu, Ying Huang, Bang-Dang Chen
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 51 Issue 12 Pg. 2331-4 (Dec 2013) ISSN: 1437-4331 [Electronic] Germany
• PMID: 23940069 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• SAA1 protein, human
• Serum Amyloid A Protein

Topics

• Blood Glucose (analysis)
• China
• Genotype
• Humans
• Polymerase Chain Reaction
• Polymorphism, Genetic (genetics)
• Serum Amyloid A Protein (genetics)