Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study.

Abstract

BACKGROUND:

Abnormal expression of Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin), a novel member of the inhibitor of apoptosis protein (IAP) family, has implications in many types of cancer and is considered as a new therapeutic target. We suppose that genetic variant rs9904341 in the 5' UTR region of survivin gene may be associated with the development and progression of prostate cancer (PCa) in Chinese population.

METHODS:

TaqMan assay method was used to genotype the polymorphism in the hospital-based case-control analysis of 665 patients with PCa and 710 age-matched cancer-free controls. The genetic associations with the occurrence and progression of PCa were calculated by logistic regression.

RESULTS:

Our results indicated that compared with GG genotypes, there was a statistically significant increased risk of PCa associated with those with CC genotypes [odds ratios (ORs) = 1.57, 95%confidence intervals (CIs) = 1.17-2.13, P = 0.004]. Moreover, stratification analysis revealed that the association was more pronounced in subgroups of nondrinkers, nonsmokers and those without a family history of cancer (all P < 0.05). In addition, we observed that PSA ≥ 20 was more frequent in patients carrying GC/CC genotypes than in those with a wild type genotype.

CONCLUSION:

The functional survivin rs9904341 genetic variant may have a substantial influence on the PCa susceptibility and evolution.

• Authors: Jiawei Chen, Xinhai Cui, Hai Zhou, Chao Qin, Qiang Cao, Xiaobing Ju, Pu Li, Hongzhou Cai, Jian Zhu, Xiaoxin Meng, Meilin Wang, Zhengdong Zhang, Pengfei Shao, Jie Li, Changjun Yin
• Journal: BMC cancer (BMC Cancer) Vol. 13 Pg. 356 (Jul 24 2013) ISSN: 1471-2407 [Electronic] England
• PMID: 23883402 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BIRC5 protein, human
• Inhibitor of Apoptosis Proteins
• Survivin
• Prostate-Specific Antigen

Topics

• Aged
• Aged, 80 and over
• Alleles
• Asian People (genetics)
• Case-Control Studies
• China
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Inhibitor of Apoptosis Proteins (genetics)
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic
• Prostate-Specific Antigen (metabolism)
• Prostatic Neoplasms (genetics, metabolism, pathology)
• Risk Factors
• Survivin