Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.

Abstract

Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.

• Authors: Phuong Thien Thuong, Tran Manh Hung, Nguyen Minh Khoi, Hoang Thi My Nhung, Nguyen Thi Chinh, Nguyen Thi Quy, Tae Su Jang, Minkyun Na
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 37 Issue 3 Pg. 399-403 (Mar 2014) ISSN: 1976-3786 [Electronic] Korea (South)
• PMID: 23877238 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Cytotoxins
• Lignans

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Cytotoxins (isolation & purification, pharmacology)
• Dogs
• HeLa Cells
• Hep G2 Cells
• Humans
• Lignans (isolation & purification, pharmacology)
• MCF-7 Cells
• Madin Darby Canine Kidney Cells
• Mice
• Myristica
• Seeds
• Tumor Burden (drug effects, physiology)
• Vietnam
• Xenograft Model Antitumor Assays (methods)