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macelignan

an NSAID with antioxidant, free radical scavenging, and neuroprotective activities; structure in first source

Networked: 17 relevant articles (1 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        macelignan: 17

Experts

1.	Hwang, Jae-Kwan: 6 articles (06/2013 - 01/2007)
2.	Han, Jung-Soo: 4 articles (03/2013 - 06/2005)
3.	Hwang, Jae Kwan: 4 articles (03/2013 - 06/2005)
4.	Ha, Ilho: 3 articles (01/2009 - 06/2005)
5.	Han, Kyu Lee: 3 articles (03/2008 - 01/2007)
6.	Hwang, Yoo Kyeong: 2 articles (06/2009 - 12/2008)
7.	Jin, Da-Qing: 2 articles (12/2008 - 06/2005)
8.	Sohn, Jong Hee: 2 articles (02/2008 - 01/2007)
9.	Bi, Decheng: 1 article (01/2022)
10.	Cai, Nan: 1 article (01/2022)

Related Diseases

1.	Body Weight (Weight, Body) 04/20/2020 - "The rats were randomly assigned to five groups of 10 rats each: sham treated group, IRI group and 40 mg macelignan/kg body weight (bwt) group, 80 mg macelignan/kg bwt group, and 160 mg macelignan/kg bwt group. " 03/01/2008 - "Furthermore, macelignan significantly improved glucose and insulin tolerance in these mice, and without altering food intake, their body weights were slightly reduced while weights of troglitazone-treated mice increased. "
2.	Insulin Resistance 03/01/2008 - "Macelignan enhanced insulin sensitivity and improved lipid metabolic disorders by activating PPARalpha/gamma and attenuating ER stress, suggesting that it has potential as an antidiabetes agent for the treatment of type 2 diabetes."
3.	Type 2 Diabetes Mellitus (MODY) 03/01/2008 - "Macelignan enhanced insulin sensitivity and improved lipid metabolic disorders by activating PPARalpha/gamma and attenuating ER stress, suggesting that it has potential as an antidiabetes agent for the treatment of type 2 diabetes."
4.	Pneumonia (Pneumonitis) 06/13/2013 - "Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases." 06/13/2013 - "The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma. " 06/13/2013 - "Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma."
5.	Neoplasm Metastasis (Metastasis) 01/01/2024 - "In the present study, we reveal a previously unrecognized mechanism of macelignan in the prevention of CRC metastasis and demonstrate its effectively and safely therapeutic potential in CRC treatment." 01/01/2024 - "Macelignan suppressed macrophage M2 polarization via ROS-mediated PI3K/AKT signaling pathway, thus preventing IL-1β/NF-κB-dependent CRC metastasis. " 01/01/2024 - "Mechanistically, macelignan reduced secretion of IL-1β from M2 macrophages, which in turn blocked NF-κB p65 nuclear translocation and inhibited metastasis. " 01/01/2024 - "Furthermore, macelignan inhibited M2 macrophage-mediated metastasis of CRC cells in vitro and in vivo. " 01/01/2024 - "In vitro and in vivo function assays were performed to investigate the roles of macelignan in CRC metastasis. "

Related Drugs and Biologics

1.	PPAR alpha
2.	Lipids
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Troglitazone (Rezulin)
6.	Member 1 Subfamily B ATP Binding Cassette Transporter
7.	Lignans
8.	Skin Lightening Preparations
9.	Phytoestrogens (Phytoestrogen)
10.	Rhodamine 123

Related Therapies and Procedures

1.	Therapeutics
2.	Mongolian Traditional Medicine