The cGAS-STING pathway for DNA sensing.

Abstract

The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms of cGAMP generation. Concurrent studies also reveal unique phosphodiester linkages in endogenous cGAMP that distinguish it from microbial cGAMP and other cyclic dinucleotides. Together, these studies provide a new perspective on DNA recognition in the innate immune system.

• Authors: T Sam Xiao, Katherine A Fitzgerald
• Journal: Molecular cell (Mol Cell) Vol. 51 Issue 2 Pg. 135-9 (Jul 25 2013) ISSN: 1097-4164 [Electronic] United States
• PMID: 23870141 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Membrane Proteins
• STING1 protein, human
• DNA
• Nucleotidyltransferases
• cGAS protein, human

Topics

• Biosensing Techniques
• DNA (metabolism)
• Humans
• Membrane Proteins (metabolism)
• Nucleotidyltransferases (metabolism)
• Second Messenger Systems