Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.

Abstract

OBJECTIVE:

To examine whether serum uric acid (SUA) is associated with 2-hour postload glucose (2-h PG) in Chinese with impaired fasting plasma glucose (IFG) and/or HbA1c (IA1C).

RESEARCH DESIGN AND METHODS:

Anthropometric and biochemical examinations, such as SUA concentration, were performed in 3763 individuals from all the villages in Baqiao County, China. A 75-g oral glucose tolerance test (OGTT) was conducted in 1197 Chinese with prediabetes as having IFG (110 ≤ fasting plasma glucose [FPG] <126 mg/dl and HbA1c <6.5%), IA1C (5.7% ≤ HbA1c <6.5% and FPG <126 mg/dl), or both.

RESULTS:

The present study included 1197 participants with IFG and/or IA1C (mean age 56.5 ± 10.3 years; 50.6% men). In multivariate linear regression, after adjustment for gender, age, smoking and drinking, body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), lipid profiles, logarithmic transformed C-reactive protein (log-CRP), estimated glomerular filtration rate (e-GFR), FPG and HbA1c, with a 1-mg/dl increment of SUA, 2-h PG increased by 5.04 ± 0.72 (P<0.001), 3.06 ± 1.08 (P = 0.001), 5.40 ± 1.26 (P<0.001), and 2.34 ± 2.16 mg/dl (P = 0.056) in all participants, in participants with normal glucose tolerance (NGT), with impaired glucose tolerance (IGT), and with 2-h newly diagnosed diabetes (2-h NDM, with 2-h PG ≥ 200 mg/dl), respectively. In both men and women, 2-h PG increased progressively and significantly from the lower to the upper SUA tertiles (P<0.001). Moreover, in multivariate logistic regression, 1-standard deviation (SD; 1.53 mg/dl) increment of SUA was significantly associated with a 36% higher risk for 2-h NDM (Odds ratio [CI 95%]: 1.36 [1.09-1.99]; P = 0.03).

CONCLUSIONS:

SUA is significantly associated with 2-h PG in Chinese with IFG and/or IA1C.

• Authors: Hong-Qi Fan, Wei Tang, Zhi-Xiao Wang, Su-Juan Wang, Yue-Hua Qin, Qi Fu, Yuan Gao, Min Sun, Mei Zhang, Hong-Wen Zhou, Tao Yang
• Journal: PloS one (PLoS One) Vol. 8 Issue 7 Pg. e67759 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23844086 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Uric Acid

Topics

• Aged
• Asian People
• Blood Glucose
• China
• Fasting (blood)
• Female
• Glucose Intolerance
• Glucose Tolerance Test
• Glycated Hemoglobin (metabolism)
• Humans
• Male
• Middle Aged
• Odds Ratio
• Risk Factors
• Sex Factors
• Uric Acid (blood)