HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Multimodal evaluation of xenograft tumors in mice with an in-vivo stereo imaging system and small-animal PET/CT.

Abstract
In small-animal studies, calipers are the standard method used for measurement of external tumor size. However, as tumors are not usually prolate spheroids, this may lead to inaccuracies in the data. Also, correlations vary according to the kind and size of tumors. Tumors were generated by transplanting B16 mouse melanoma cells into the back of Balb/c nude mice. True volumes were measured by calipers, an in-vivo stereo imaging system, and as a standard uptake value (SUV) by (18)F-fluorodeoxyglucose ([(18)F]FDG)-PET. Correlations between measurements were analyzed. Correlation with the true volume was higher for measurements using the in-vivo stereo imaging system (r = 0.876) than with calipers (r = 0.744). Measurement of melanoma volume has a larger measuring error when performed using a caliper compared with measurements performed by stereo imaging when the volume of the melanoma is small. Correlation of the volume and PET-SUV by a caliper is low as the size of the melanoma increases. This same relationship exists with the comparison of stereo imaging and PET-SUV. The correlation between the SUV of [(18)F]FDG-PET and tumor volume with the melanoma is expected to be important in related future studies.
AuthorsOnseok Lee, Gunwoo Lee, Mingi Kim, Seok-Ki Kim, Yoosang Baek, Chilhwan Oh
JournalMelanoma research (Melanoma Res) Vol. 23 Issue 5 Pg. 349-59 (Oct 2013) ISSN: 1473-5636 [Electronic] England
PMID23839076 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
Topics
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Fluorodeoxyglucose F18
  • Male
  • Melanoma, Experimental (diagnosis, diagnostic imaging, pathology)
  • Mice, Inbred BALB C
  • Mice, Nude
  • Multimodal Imaging (methods)
  • Neoplasm Transplantation
  • Positron-Emission Tomography
  • Predictive Value of Tests
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Tomography, X-Ray Computed
  • Tumor Burden

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: