Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer.

Abstract

DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach. Minimizing oxidative damage may be a significant advance in the prevention or treatment of these diseases, since antioxidants are able to stop the free-radical formation and prevent oxidizing chain reactions. These findings have generated great interest in therapeutic antioxidant-based cancer drug development. The design and development of synthetic compounds, able to scavenge free radicals, could present a significant therapeutic advance, in particular for treating pathological conditions such as cancer. This article will outline the state of the research on the relationship between antioxidant therapy and cancer, describing the new synthetic antioxidant molecules that have anticancer activities. Investigations and association between dietary antioxidants, oxidative stress, and cancer will be also discussed.

• Authors: Betul Tekiner-Gulbas, Andrew D Westwell, Sibel Suzen
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 20 Issue 36 Pg. 4451-9 ( 2013) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 23834180 (Publication Type: Journal Article, Review)

Chemical References

• Anticarcinogenic Agents
• Antioxidants
• Free Radicals
• Reactive Oxygen Species
• DNA

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Antioxidants (pharmacology)
• Carcinogenesis (metabolism)
• DNA (drug effects, genetics, metabolism)
• DNA Mutational Analysis
• Free Radicals (chemistry, metabolism)
• Humans
• Neoplasms (drug therapy, genetics, metabolism, prevention & control)
• Oxidative Stress (drug effects, physiology)
• Reactive Oxygen Species (metabolism)