Abstract | BACKGROUND AND AIMS:
Cryptococcal meningitis (CM) has gradually increased in the recent 20 years in the whole world. Although the mortality decreased significantly in recent years, it was still high, especially in patients with persistent infection. Therefore, we compare differences of clinical features between persistent and nonpersistent CM patients. METHODS: We conducted a retrospective review of medical records of patients diagnosed with CM from January 2000 to December 2011 in four centers in China, including demographic features, underlying diseases, clinical presentations, laboratory data, and so on. RESULTS: Of 106 CM patients enrolled, 16 were identified as persistent cases. Among all variables, persistent CM patients were more like to be human immunodeficiency viruses ( HIV) infection (P < 0.05), stiff neck (P < 0.01), a serum hemoglobin < 90 g/L (P < 0.01), a serum potassium concentration <2.7 mg/L (P < 0.01), an intracranial pressure (ICP) >400 mmH2 O (P < 0.01), and a latex agglutination cryptococcal antigen titer of cerebrospinal fluid (CSF LACT) >1:1024 (P < 0.01) than nonpersistent ones. A multivariate analysis showed that HIV infection (OR 7.49), stiff neck (OR 11.7), a serum potassium <2.7 mmol/L (OR 9.45), and an ICP >400 mmH2 O (OR 6.83) were closely correlated with persistent CM. CONCLUSIONS: Although it is difficult to deal with persistent CM nowadays, some cases could be predicted early enough in the future, so as to be treated appropriately and have relatively good outcomes.
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Authors | Xiao-Guang Xu, Wei-Hua Pan, Xin-Ling Bi, Wei Fang, Min Chen, Yu Zhu, Jie Zhou, Nan Zhou, Bo Pan, Meng Li, Wan-Qing Liao, Zhong-Tian Qi |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 19
Issue 8
Pg. 625-31
(Aug 2013)
ISSN: 1755-5949 [Electronic] England |
PMID | 23795869
(Publication Type: Case Reports, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Topics |
- Adult
- China
(epidemiology)
- Chronic Disease
- Female
- Follow-Up Studies
- Humans
- Male
- Meningitis, Cryptococcal
(diagnosis, epidemiology, metabolism)
- Middle Aged
- Retrospective Studies
- Time Factors
- Young Adult
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