[Estimation of activity of bis-netropsin derivatives based on a model of an experimental cutaneous herpes simplex virus disease of guinea pigs].

Abstract

Using the model of an experimental cutaneous infection of guinea pig males caused by herpes simple virus type 1, it is shown that application of dimerico derivatives of netropsin Lys-bis Nt and 15Lys-bis Nt in the form of polietilenglicol-based ointment suppresses viral infection more effectively than acyclovir.

• Authors: V L andronova, S L Grokhovskiĭ, A N Surovaia, G V Gurskiĭ, P G Deriabin, D K L'vov, G A Galegov
• Journal: Voprosy virusologii (Vopr Virusol) 2013 Jan-Feb Vol. 58 Issue 1 Pg. 32-5 ISSN: 0507-4088 [Print] Russia (Federation)
• PMID: 23785759 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Ointments
• Netropsin
• Acyclovir

Topics

• Acyclovir (pharmacology)
• Administration, Topical
• Animals
• Antiviral Agents (pharmacology)
• Disease Models, Animal
• Guinea Pigs
• Herpes Simplex (drug therapy, pathology)
• Herpesvirus 1, Human
• Male
• Netropsin (analogs & derivatives, pharmacology)
• Ointments