Manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant.

Abstract

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.

• Authors: Giuseppe Bersani, Pietropaolo Marino, Giuseppe Valeriani, Valentina Cuoco, Claudia Zitelli, Claudia Melcore, Francesco Saverio Bersani
• Journal: Case reports in psychiatry (Case Rep Psychiatry) Vol. 2013 Pg. 926395 ( 2013) ISSN: 2090-682X [Print] United States
• PMID: 23762723 (Publication Type: Journal Article)