Abstract | BACKGROUND: METHODS: RESULTS: Among women with histories of mood disorders, the mean RBC folate concentration was 674 nmol/L (range, 362-1105 nmol/L). Only 12.5% (n = 3) of the women had RBC folate concentrations >906 nmol/L, despite all participants reporting current daily use of folic acid supplements. Data regarding offspring were available for 22 women: birth weights ranged from 2296 g to 4819 g, and congenital abnormalities were identified in two (hypoplastic left heart, annular pancreas). CONCLUSION: Data from this exploratory case series suggest a need for future larger scale controlled studies investigating RBC folate concentrations in early pregnancy and offspring outcomes among women with and without histories of mood disorders.
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Authors | Elyse Yaremco, Angela Inglis, Sheila M Innis, Catriona Hippman, Prescilla Carrion, Yvonne Lamers, William G Honer, Jehannine Austin |
Journal | Birth defects research. Part A, Clinical and molecular teratology
(Birth Defects Res A Clin Mol Teratol)
Vol. 97
Issue 6
Pg. 416-20
(Jun 2013)
ISSN: 1542-0760 [Electronic] United States |
PMID | 23760977
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- British Columbia
- Dietary Supplements
(statistics & numerical data)
- Erythrocytes
(metabolism)
- Female
- Folic Acid
(blood)
- Humans
- Mood Disorders
(blood)
- Pregnancy
- Pregnancy Outcome
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