Abstract | PURPOSE: METHODS: We used the 2001-2004 National Health and Nutrition Examination Survey (NHANES) to investigate the associations between eight monohydroxy urinary metabolites of four PAHs and PAD. RESULTS: In a logistic regression model, subjects within the middle and highest tertiles of fluorene metabolites, 2-hydroxyfluorene (2-FLUO) and 3-hydroxyfluorene (3-FLUO), and phenanthrene metabolites, 1-hydroxyphenanthrene (1-PHEN) and 2-hydroxyphenanthrene (2-PHEN), had significantly higher prevalence of PAD as compared to subjects within the lowest tertile after adjusting for cigarette smoking, diabetes mellitus and other covariates (For 2-FLUO, the 3rd tertile: OR=2.22, 95% CI=1.13-4.37, p for trend=0.02; For 3-FLUO, the 3rd tertile: OR=2.36, 95% CI: 1.16-4.77, p for trend=0.02; For 1-PHEN, the 3rd tertile: OR=1.84, 95% CI: 1.01-3.37, p for trend=0.04; For 2-PHEN, the 3rd tertile: OR=1.76, 95% CI: 1.07-2.88, p for trend=0.03). CONCLUSIONS: Our findings suggest that exposure to PAHs may increase the risk of PAD. Further studies are necessary to explore the associations between PAHs and PAD.
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Authors | Xiaohui Xu, Hui Hu, Gregory D Kearney, Haidong Kan, David S Sheps |
Journal | The Science of the total environment
(Sci Total Environ)
Vol. 461-462
Pg. 341-7
(Sep 01 2013)
ISSN: 1879-1026 [Electronic] Netherlands |
PMID | 23747551
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Polycyclic Aromatic Hydrocarbons
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Topics |
- Biomarkers
(urine)
- Environmental Exposure
(adverse effects)
- Humans
- Logistic Models
- Nutrition Surveys
- Peripheral Arterial Disease
(chemically induced, epidemiology)
- Polycyclic Aromatic Hydrocarbons
(adverse effects, urine)
- United States
(epidemiology)
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