Effectiveness of seasonal influenza vaccine against clinically diagnosed influenza over 2 consecutive seasons in children in Guangzhou, China: a matched case-control study.

Abstract

Influenza vaccine has to be reformulated each year due to the ever-changing antigenicity of the influenza virus. However, few post-licensure studies of influenza vaccine are available in China. We aimed to measure the effectiveness of seasonal influenza vaccine during 2 consecutive seasons. Among children in Guangzhou aged 6 to 59 mo in 2010-2012, we matched each child with clinically diagnosed influenza to 3 healthy children. Cases with clinically diagnosed influenza were identified from surveillance system. Healthy controls were randomly sampled from the Children's Expanded Programmed Immunization Administrative Computerized System. Conditional logistic regression was used to calculate vaccine effectiveness (VE). A total of 275 matched sets of subjects were included. VE levels against clinically diagnosed influenza for both seasons combined was 47.4% [95% confidence interval (CI), 8.5-69.8%] for full vaccination for children aged 6-35 mo, 33.6% (95% CI, 5.4-53.5%) for any vaccination for children aged 6-59 mo, respectively. VE by time since vaccination for any vaccination was 34.6% (95% CI, 4.7-55.2%) in 0-5 mo, and no protection was observed in 6-11 mo. Annual, full and timely vaccination should be encouraged for children.

• Authors: Qing He, Jianxiong Xu, Xi Chen, Jianyun Lu, Kuibiao Li, Zhaotian Li, Ming Wang, Qiongying Yang, Zhiqiang Dong, Xiangyi Liu, Xuehong Wu, Wensui Hu, Danfeng Zhang, Jiayun Lv, Jun Nie, Wei Zhu, Chuanxi Fu
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 9 Issue 8 Pg. 1720-4 (Aug 2013) ISSN: 2164-554X [Electronic] United States
• PMID: 23733038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Influenza Vaccines

Topics

• Case-Control Studies
• Child, Preschool
• China (epidemiology)
• Female
• Humans
• Infant
• Influenza Vaccines (administration & dosage, immunology)
• Influenza, Human (epidemiology, prevention & control)
• Male
• Product Surveillance, Postmarketing