Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistance.

Abstract

OBJECTIVE:

This study investigates the expression of Lewis y antigen, integrin αv, β3 in epithelial ovarian cancer tissues. We further evaluate the relationship between their expression and chemotherapy resistance of ovarian cancer and its possible clinical significance.

METHODS:

Tissues of 92 patients with ovarian cancer meeting the inclusion criteria with complete follow-up data were enrolled and divided into chemotherapy resistant group and sensitive group. The expression and relationship of Lewis y antigen and integrin αv, β3 are assessed in paraffin sections using immunohistochemistry and double-labeling immunofluorescence method. Multivariate logistic regression analysis was used to investigate the relationship between age, clinical stage, differentiation, histologic subtype, Lewis y antigen and integrin αv, β3 expression in ovarian cancer patients.

RESULTS:

The expression rates of Lewis y antigen and integrin αv in the resistant group, significantly higher than the rates found in the sensitive group (p <0.05). Multivariate analysis showed that the expression of Lewis y antigen, integrin αv and ovarian cancer's clinical stage were independent, drug resistance-related risk factors. The expression levels of Lewis y antigen and integrin αv, β3 were positively correlated with each other.

CONCLUSIONS:

A close correlation between Lewis y antigen, integrin αv, β3 and ovarian cancer was observed. Lewis y antigen can influence the biological behavior of a tumor cell as an important composition of integrin αv, β3 by some signal pathway. And the expression of Lewis y antigen, integrin αv and ovarian cancer's clinical stage are both independent, drug resistance-related risk factors.

• Authors: Jian Gao, Zhenhua Hu, Dawo Liu, Juanjuan Liu, Chuan Liu, Rui Hou, Song Gao, Danye Zhang, Shulan Zhang, Bei Lin
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 32 Pg. 36 (Jun 01 2013) ISSN: 1756-9966 [Electronic] England
• PMID: 23725446 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Integrin alphaV
• Integrin beta3
• Lewis Blood Group Antigens
• Lewis Y antigen

Topics

• Antineoplastic Agents (therapeutic use)
• Drug Resistance, Neoplasm (genetics)
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• Integrin alphaV (genetics, metabolism)
• Integrin beta3 (genetics, metabolism)
• Lewis Blood Group Antigens (genetics, metabolism)
• Neoplasm Grading
• Neoplasm Staging
• Ovarian Neoplasms (drug therapy, metabolism, pathology)