For which cancer types can neuron-specific enolase be clinically helpful in Turkish patients?

The aim of the present study was to evaluate the serum neuron-specific enolase (NSE) levels in patients with prostate cancer, Hodgkin lymphoma, lung cancer and peripheral nerve tumors.
NSE levels were determined by ELISA in the sera of 100 prostate cancer, 47 Hodgkin lymphoma, 35 lung cancer and 35 peripheral nerve tumor patients and also in 132 healthy controls.
The median levels of serum NSE were elevated in patients with lung cancer (p=0.018) and peripheral nerve tumors (p=0.008). NSE levels in prostate cancer and Hodgkin lymphoma patients were higher than the controls but there was no statistically significant difference (p>0.05).
We conclude that NSE may be applied in routine to gain insight about the clinical statuses of various cancer patients, but more studies are needed to determine the organ specificity.
AuthorsElif Bilgin, Yavuz Dizdar, Murat Serilmez, Hilal Oguz Soydinc, Ceren Tilgen Yasasever, Derya Duranyildiz, Vildan Yasasever
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 4 Pg. 2541-4 ( 2013) ISSN: 1513-7368 [Print] Thailand
PMID23725171 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Phosphopyruvate Hydratase
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (blood)
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Hodgkin Disease (blood, diagnosis, enzymology)
  • Humans
  • Infant
  • Lung Neoplasms (blood, diagnosis, enzymology)
  • Male
  • Middle Aged
  • Peripheral Nervous System Neoplasms (blood, diagnosis, enzymology)
  • Phosphopyruvate Hydratase (blood)
  • Prognosis
  • Prostatic Neoplasms (blood, diagnosis, enzymology)
  • ROC Curve
  • Turkey
  • Young Adult

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