Scrub typhus and cerebrovascular injury: a phenomenon of delayed treatment?

Abstract	Abstract. Three patients diagnosed with scrub typhus through serology and polymerase chain reaction tests, experienced delayed administration of effective antibiotics after the appearance of symptoms, presented with subdural hemorrhage, intracerebral hemorrhage, or cerebral infarction in the late acute phase. Orientia tsutsugamushi should be considered as a causal or provoking factor for cerebrovascular accidents in regions where scrub typhus is endemic, especially in those who receive delayed treatment.
Authors	Jong-Hoon Chung, Na-Ra Yun, Dong-Min Kim, Ji-Woon Lee, Sung Ho Yoon, Seok-Won Kim
Journal	The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 89 Issue 1 Pg. 119-22 (Jul 2013) ISSN: 1476-1645 [Electronic] United States
PMID	23716407 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Bacterial Agents
Topics	Aged Aged, 80 and over Anti-Bacterial Agents (therapeutic use) Brain (diagnostic imaging) Cerebral Hemorrhage (etiology, microbiology) Cerebral Infarction (etiology, microbiology) Cerebrovascular Disorders (etiology, microbiology) Delayed Diagnosis Fatal Outcome Female Hematoma, Subdural (etiology, microbiology) Humans Male Middle Aged Neuroimaging Orientia tsutsugamushi Republic of Korea Scrub Typhus (complications, diagnosis, drug therapy) Tomography, X-Ray Computed

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