Abstract | BACKGROUND AND PURPOSE: METHODS: In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA1c was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days. RESULTS: A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3-5). In univariate analysis history of diabetes mellitus, HbA1c, blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA1c were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA1c when Safe Implementation of Treatments in Stroke criteria were used. CONCLUSIONS:
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Authors | Andrea Rocco, Peter U Heuschmann, Peter D Schellinger, Martin Köhrmann, Jennifer Diedler, Marek Sykora, Christian H Nolte, Peter Ringleb, Werner Hacke, Eric Jüttler |
Journal | Stroke
(Stroke)
Vol. 44
Issue 8
Pg. 2134-8
(Aug 2013)
ISSN: 1524-4628 [Electronic] United States |
PMID | 23715962
(Publication Type: Journal Article)
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Chemical References |
- Fibrinolytic Agents
- Glycated Hemoglobin A
- Tissue Plasminogen Activator
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Topics |
- Aged
- Aged, 80 and over
- Cerebral Hemorrhage
(blood, etiology)
- Female
- Fibrinolytic Agents
(administration & dosage, adverse effects)
- Glycated Hemoglobin
(analysis)
- Humans
- Male
- Predictive Value of Tests
- Retrospective Studies
- Risk
- Stroke
(blood, drug therapy)
- Thrombolytic Therapy
(adverse effects)
- Tissue Plasminogen Activator
(administration & dosage, adverse effects)
- Treatment Outcome
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