Remarkable anti-breast cancer activity of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines.

Abstract

A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of (1)H NMR, (13)C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.

• Authors: Jagannath Jadhav, Aarti Juvekar, Rajanikant Kurane, Sharanabasappa Khanapure, Rajashri Salunkhe, Gajanan Rashinkar
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 65 Pg. 232-9 (Jul 2013) ISSN: 1768-3254 [Electronic] France
• PMID: 23711834 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Chemical References

• 1,4-dihydropyrimidine
• Antineoplastic Agents
• Ferrous Compounds
• Metallocenes
• Pyrimidines
• ferrocene

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Breast Neoplasms (drug therapy, pathology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Ferrous Compounds (chemistry)
• Humans
• Metallocenes
• Molecular Structure
• Pyrimidines (chemical synthesis, chemistry, pharmacology)
• Structure-Activity Relationship