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Chalcones

Derivatives of CHALCONE that are important intermediates in the formation of FLAVONOIDS with anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties.
Also Known As:
1,3-Diphenyl-propanediones; 1,3-Diphenyl-propenones; 1,3-Diphenylpropanediones; 1,3-Diphenylpropenones; Chalconoids; 1,3 Diphenyl propanediones; 1,3 Diphenyl propenones; 1,3 Diphenylpropanediones; 1,3 Diphenylpropenones
Networked: 412 relevant articles (10 outcomes, 67 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Nunes, Ricardo José: 10 articles (11/2021 - 09/2008)
2. Yunes, Rosendo Augusto: 9 articles (02/2021 - 12/2008)
3. Mascarello, Alessandra: 9 articles (01/2018 - 12/2008)
4. Nunes, Ricardo J: 7 articles (01/2022 - 02/2012)
5. Marins, Mozart: 7 articles (10/2021 - 10/2016)
6. Silva, Gabriel: 6 articles (08/2021 - 10/2016)
7. Winter, Evelyn: 6 articles (01/2015 - 05/2013)
8. Santos-Silva, Maria Cláudia: 5 articles (11/2021 - 09/2010)
9. Fachin, Ana Lúcia: 5 articles (10/2021 - 10/2016)
10. Mathew, Bijo: 5 articles (10/2021 - 01/2019)

Related Diseases

1. Neoplasms (Cancer)
2. Prostatic Neoplasms (Prostate Cancer)
3. Inflammation (Inflammations)
4. Carcinogenesis
5. Edema (Dropsy)
10/15/2013 - "The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. "
04/01/2011 - "Chalcones of 2a-f and their corresponding products, pyrazolines 3a-f, were synthesized and evaluated for their anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. "
06/01/2013 - "Some unnatural chalcones (1a-q) and flavones (2a-d) have been synthesized and evaluated for their antiinflammatory activity using carrageenan-induced rat paw edema assay. "
09/01/1994 - "Fourteen flavonoids (flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. "
05/01/2006 - "The synthesis of 1,3-diaryl propen-1-ones (chalcones) by the Claisen-Schmidt condensation between acetophenones and benzaldehydes in potassium hydroxide/methanol medium at room temperature yielded: 1-(4-nitrophenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3a), 1-(4-nitrophenyl)-3-(3-bromophenyl)propen-1one (3b), 1-(4-methoxyphenyl)-3-(3-bromophenyl)propen-1-one (3c), 1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3d), 1-(2,4-dihydroxyphenyl)-3-(phenyl)propen-1-one (3e), 1-(4-nitrophenyl)-3-(4-chlorophenyl)propen-1-one (3f) which were evaluated for anti-inflammatory activity at doses of 20, 40 and 80mg/kg. The compounds were found to be effective inhibitors of carrageenan-induced rat paw edema in Wistar rats and this activity was dose dependent and increased between the third and fourth hour. "

Related Drugs and Biologics

1. Flavonoids
2. Tubulin
3. Stilbenes
4. Carrageenan
5. Matrix Metalloproteinases (MMPs)
6. Type II DNA Topoisomerases (Topoisomerase II)
7. Aromatase (CYP19)
8. Cathepsin K
9. Proteasome Endopeptidase Complex (Proteasome)
10. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1. Chemoprevention
2. Traditional Medicine (Folk Remedies)
3. Therapeutics
4. Drug Therapy (Chemotherapy)
5. Radiotherapy