[Application and development of quantum dots in the imaging of lymph node metastasis].

Abstract

Quantum dots(QDs) are semiconductor nanocrystals composed of element from the periodic groups of II(-IIIIII( or III(-IIIII(, which possess wide excitation spectra and narrow emission spectra. The maximum emission wavelength of QDs can be controlled in a relatively simple manner by variation of particle size and composition. QDs can be tuned at a variety of precise wavelengths from ultraviolet(UV) to near infrared(NIR). QDs can be conjugated to a wide range of biological targets, including monoclonal antibodies, proteins, polymers and nucleic acid probes. These characteristics make it not only for revealing interaction of nucleic acids, proteins and other biological macromolecules, by biological imaging but also for detection of lymph node metastasis through preoperative and introperative lymphatic imaging. Along with the continuously improvement of observation techniques and quantum dot structure optimization in recent years, the research on lymph node imaging is ongoing.

• Authors: Wen-Xian Guan, Li-Jiang Hu
• Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery (Zhonghua Wei Chang Wai Ke Za Zhi) Vol. 16 Issue 5 Pg. 415-7 (May 2013) ISSN: 1671-0274 [Print] China
• PMID: 23696394 (Publication Type: Journal Article)

Chemical References

• Proteins

Topics

• Diagnostic Imaging
• Lymph Nodes
• Lymphatic Metastasis
• Proteins
• Quantum Dots